Karaganda Medical University
«Medicine and Ecology» journal
Monthly newspaper «Medic»

Committee of the Ministry of Education and Science of Kazakhstan (program and target financing)

Scientific and technical program О.0821 «Personalized approach in the management of a number of significant diseases»

Term of execution - 2018-2020 years

Supervisor – Doctor of Medical Sciences A. Turmukhambetova

State registration No. 0118РК01034

Collaborators:

"Hospital of the Medical Center for Administration of Affairs of the President of the Republic of Kazakhstan" RSE.

The objective of the program is development of a scientific basis for a personalized approach in the management of a number of significant diseases based on the molecular genetic characteristics of patients.

Tasks:

1.  Search and estimation of the biomarkers associating with colorectal cancer among the representatives of the main ethnic groups of Kazakhstan.

2.  The development of personalized approaches in colorectal cancer chemotherapy.

3.  Search and evaluation of the main genetic markers of resistance to antiplatelet therapy in patients with coronary heart disease among representatives of the main ethnic group of Kazakhstan.

4.  Study of genetic determinants associated with remodeling of the cardiovascular system.

Committee of the Ministry of Education and Science of RK (grant financing of scientific researches)

1.  Development and use of the allograft impregnated with antibiotic, prepared according to the Marburg system of the bone bank for the treatment of osteomyelitis.

Research supervisor – Doctor of Medical Sciences, professor B. Tuleubayev (2018-2020, No. SR 0118RK01020);

2.  Assessment of occupational risks and health status of persons working in the mining industry of Central Kazakhstan.

Research supervisor – Doctor of Medical Sciences, professor E. Sraubaev (2018-2020, No. SR 0118RK01016);

3.  Application of extracellular matrix xenobrain in reconstructive surgery and operative urology.

Research supervisor – Candidate of Medical Sciences, N. Abatov (2018-2020, No. SR 0118RK01010);

4.  Clinico-physiological basis for the early diagnosis of pulmonary hypertension in infants.

Research supervisor – Doctor of Medical Sciences, professor F. Mindubaeva (2018-2020, No. SR 0118RK01015);

5.  Complex assessment of the phenomenon of bacterial translocation in tissues, internal organs and systemic blood flow on models of intestinal obstruction.

Research supervisor – Doctor of Medical Sciences, professor E. Turgunov (2018-2020, No. SR 0118RK01018).

6. Ecology and health of knowledge workers in the age aspect (on the example of university teachers).

Research supervisor - Doctor of Medical Sciences,professor N. Smagulov (2018-2020, No.SR 0118RK01353);

7. Immunological aspects of neonatal sepsis.

Research supervisor - Candidate of Medical Sciences L. Akhmaltdinova (2020-2022, No.SR 0120RK00187);

8. Development of the composition and technology of original herbal medicines for the treatment and prevention of Helicobacter pylori - associated diseases.

Research supervisor - Doctor of Pharmaceutical Sciences, professor S. Ivasenko (2020-2021, No.GR 0120RK00277);

9. Detection of biomarkers of bacterial translocation in the early diagnosis of infectious and inflammatory complications in patients with intestinal obstruction of tumor origin.

Research supervisor -Doctor of Medical Sciences, professor E. Turgunov (2020-2021, No. GR 0120RK00245);

10. Prognostic assessment of the influence of clinical and genetic factors on the risk of development and the nature of the course of the disease in spontaneous intracerebral hemorrhage.

Research supervisor -Candidate of Medical Sciences N. Tursynov (2020-2021, No. GR 0120RK00254).

Clinical trials

1. Study in accordance with Record No. M14-465 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate or severe active rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and which have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).

Research supervisor – Candidate of Medical Sciences, associate professor A. Alina.

2. Study under Record No. M13-545 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate to severe severe rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).

Research supervisor – Candidate of Medical Sciences, associate professor A. Alina.

3. Randomized placebo-controlled studies of the safety, therapeutic effectiveness of the oral form of the drug FS-1 in the resistant forms of pulmonary tuberculosis. (Customer - Joint Stock Company "Scientific Center of Anti-Infective Drugs", Almaty).

Research supervisor – Doctor of Medical Sciences, professor N. Tabriz.

4.  A multicenter clinical study of the original drug "Arglabin" in the complex therapy of breast cancer in high doses (Customer - JSC MNPH Phytochemistry, Karaganda).

Research supervisor – Doctor of Medical Sciences, professor V. Syrota.

5. An open, blinded, randomized, controlled study of the efficacy and safety of using Reosorbilact®, solution for infusions (Yuriya-Farm, Ukraine), in comparison with Ringer-lactate, solution for infusions in the complex treatment of patients with burns disease (Customer - Cromos Pharma LLC).

Research supervisor – Candidate of Medical Sciences B. Tuleubaev.

6. Safety assessment of the effectiveness of the use of xenogenic biological coating "X-GRAFT" in the complex therapy of local treatment of burns and post-burn wounds" (Customer-X-Matrix LLP, Nur-Sultan).

Research supervisor - Candidate of Medical Sciences B. Tuleubaev.

Contractual topics

1. Membrane-cell changes in the blood of workers from exposure to chrysotile dust (Customer-JSC "Kostanay Minerals").

Research supervisor-Doctor of Medical Sciences, professor S. Ibraev.

2. Changes in the tissues and organs of experimental animals from the chronic action of chrysotile dust (Customer-JSC "Kostanay Minerals").

Research supervisor-Doctor of Medical Sciences, professor S. Ibraev.

3. Evaluation of the effectiveness of the use of freeze-dried saumal (mare's milk) in the rehabilitation of mining workers (Customer - "Evraziyainvest Ltd" LLP, Karaganda).

Research supervisor - Doctor of Medical Sciences, professor Sh. Koigeldinova.

4. Pharmacogenetic study of terpenoid molecules and molecular genetic mechanisms of their action (Customer – Joint Stock Company "International Scientific and Production Holding" Phytochemistry ", Karagandy).

Research superviser – D. Babenko, PhD.

5. Microbiological assessment of air contamination CFU / m3 after exposure to the air of the room with a DP-disinfecting device (Customer - LLP "ABsalut Ecology", Karagandy).

Research superviser – Candidate of Medical Sciences S. Akhmetova.

6. Study of the pharmacological activity of a new herbal remedy "Matripin-Dent" in the treatment of inflammatory periodontal diseases (Customer-Joint Stock Company " International Scientific and Production Holding "Phytochemistry", Karaganda).

Research supervisors – Candidate of Medical Sciences S. Akhmetova, Candidate of Medical Sciences S. Tuleutaeva.

7. Development of medicines for the correction of chronic diffuse liver diseases based on individual plant substances (Customer - L. N. Gumilyov Eurasian National University ", Nur-sultan).

Research supervisor - Doctor of Pharm. Sc. S. Ivasenko.

International grants

1.  The colonization and resistance dynamics of gram-negative aerobic isolated from hospitalized patient (SMART) (Customer - International Health Management Associates, Inc. (IHMA).

Research supervisor – A. Lavrinenko, master.