Ministry of Healthcare of the Republic of Kazakhstan (program and target financing)
Scientific and technical program О.0769 «Development of scientific bases of formation of preventive environment in order to preserve the public health»
Term of execution - 2017-2019 years
Supervisor– M.D., Professor R.S. Dosmagambetova
State registration No. 0117РК00018
Collaborators:Scientific-research institute of cardiology and internal diseases, Scientific center of pediatrics and children surgery, National center of formation of healthy lifestyle, Scientific-research institute of eye diseases of “Mark of Honor Kazakh award”, National center for occupational hygiene and occupational diseases.
Objective - the development of science-based technologies of preventive environment formation and public health strengthening
Tasks:
1) The development and improvement of technologies of impact on controllable risk factors of cardiovascular diseases at the primary healthcare level
2) The development of evidence-based recommendations for the optimization of the school environment for the preservation and strengthening of children health
3) The development of assessment technology and management of professional risks of health impairments of the workers of mining and energy industry.
Committee of the Ministry of Education and Science of Kazakhstan (program and target financing)
Scientific and technical program О.0821 «Personalized approach in the management of a number of significant diseases»
Term of execution - 2018-2020 years
Supervisor– M.D.A.A. Turmukhambetova
State registration No. 0118РК01034
Collaborators:RSE "Hospital of the Medical Center for Administration of Affairs of the President of the Republic of Kazakhstan".
Objective the development of scientific foundations for a personalized approach in the management of a number of socially significant diseases based on the molecular-genetic characteristics of patients.
Tasks:
1) Search and estimation of the biomarkers associating with colorectal cancer among the representatives of the main ethnic groups of Kazakhstan.
2)The development of personalized approaches in colorectal cancer chemotherapy.
3)Search and evaluation of the main genetic markers of resistance to antiplatelet therapy in patients with coronary heart disease among representatives of the main ethnic group of Kazakhstan.
4)Study of genetic determinants associated with remodeling of the cardiovascular system.
Committee of the Ministry of Education and Science of RK (grant financing of scientific researches)
1. Development and use of the allograft impregnated with antibiotic, prepared according to the Marburg system of the bone bank for the treatment of osteomyelitis.
Research supervisor – Doctor of Medicine, Professor B.E. Tuleubayev (2018-2020, No. ГР0118РК01020);
2. Assessment of occupational risks and health status of persons working in the mining industry of Central Kazakhstan.
Research supervisor – Doctor of Medicine, Professor E.N. Sraubaev (2018-2020, No. ГР 0118РК01016);
3. Application of extracellular matrix xenobrain in reconstructive surgery and operative urology.
Research supervisor – Candidate of Medical Sciences, N.T. Abatov (2018-2020, No.ГР 0118РК01010);
4. Clinico-physiological basis for the early diagnosis of pulmonary hypertension in infants.
Research supervisor – Doctor of Medicine, Professor F.A. Mindubaeva (2018-2020, No. ГР 0118РК01015);
5. Complex assessment of the phenomenon of bacterial translocation in tissues, internal organs and systemic
blood flow on models of intestinal obstruction.
Research supervisor – Doctor of Medicine, Professor E.M. Turgunov (2018-2020, No. ГР 0118PK01018)
Economic contractual themes
1. Membrane-cellular changes in the blood of workers from exposure to chrysotile dust (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev.
2. Changes in tissues and organs of experimental animals from chronic effects of chrysotile dust (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev.
3. Preparation of a synthesis material on the effect of chrysotile dust on the body following the results of studies at JSC "Kostanai minerals"(Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev.
4. Morphological studies of 20 animals who took the drug "Arglabin, 50 mg tablets" (Customer - JSC "MNPH" Phytochemistry ").
The scientific adviser is the doctor of medical sciences, professor G.U.Zhanaidarova
5. Attestation of production facilities for working conditions at the enterprises of JSC Petropavlovsk Branch of RZhD, Ministry of Railways (Customer - JSC Russian Railways).
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
6. Laboratory and instrumental research at workplaces of the workshop for the processing of inert materials (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
7.Elaboration of the permissible length of service and the class of working conditions as a factor of profrisk in conditions of exposure to chrysotile-containing dust from employees of the ATC and the URR. (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
8. Assessment of occupational risk in employees of the Road Transport Department (ATC) and enterprise management (UE). (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
9. Certification of production facilities for working conditions. (Customer - Nova Zinc LLP).
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
10. Determination of the level of distribution of the electromagnetic field, biologically-hazardous zone, sanitary-protective zone on the territory of the radio engineering object. (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
11.Certification of production areas of the Enterprise Department (NRP), Non-State Fire Service (NIPS), Security Service (SAT) on working conditions. (Customer - JSC "Kostanai Minerals").
The scientific adviser is the doctor of medical sciences, professor S.А.Ibraev
12. Study in accordance with Record No. M14-465 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate or severe active rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and which have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).
The scientific adviser is Candidate of Medical Science, Associate Professor A.R.Alina.
13. Study under Record No. M13-545 "Randomized, double-blind phase III study to compare ABT-494 with placebo in patients with moderate to severe severe rheumatoid arthritis who receive standard basal antirheumatic drugs at a stable dose and have not reached adequate response to them". (Customer - OOO" EbbVie", Moscow).
The scientific adviser is Candidate of Medical Science, Associate Professor A.R.Alina.
14. Conducting a clinical study of the therapeutic equivalence of the "Citicopol" drug solution for injection 1000 mg / 4ml (Customer - JSC "Khimpharm", Shymkent).
The scientific adviser - Ph.D. R.A. Belyaev.
15. Randomized placebo-controlled studies of the safety, therapeutic effectiveness of the oral form of the drug FS-1 in the resistant forms of pulmonary tuberculosis. (Customer - Joint Stock Company "Scientific Center of Anti-Infective Drugs", Almaty).
The scientific adviser is the doctor of medical sciences, professor N.S.Tabriz
16. A randomized open clinical trial of the efficacy and safety of Sausalin in comparison with Orniside in the treatment of patients with lyabliasis (Customer is JSC International Scientific and Production Holding Phytochemistry).
The scientific adviser is the doctor of medical sciences, professor R.Kh. Begaydarova
17. An international multicenter, observational, noninterventional, prospective study of the preparation of azilsartan medoxomil in patients with hypertension and overweight or obesity in the Russian Federation and the Republic of Kazakhstan (Customer - Private Limited Liability Company Crocus Medical B.V.).
The scientific adviser is the doctor of medical sciences, professor K.A. Alikhanova
18. An international multicentre, double-blind, placebo-controlled, randomized clinical trial in parallel groups of the efficacy and safety of Ergoferon in the treatment of acute respiratory viral infections in children. (Customer - Research and Production Firm "Materia Medica Holding").
The scientific adviser is the doctor of medical sciences, professor K.A. Alikhanova
Initiative themes
1. The use of fluorescent microorganisms for the detection of translocation of intestinal microflora on the model of mesenteric ischemia.
The scientific adviser is the doctor of medical sciences, professor E.M. Turgunov.
2. Evaluation of the genetic polymorphism of CYP2C19 in persons of Kazakh nationality who take clopidogrel after stenting of the coronary arteries.
The scientific adviser is the doctor of medical sciences, professor D.Z. Taizhanova.
3. Mechanisms of development and progression of nephropathy in persons with overweight.
The scientific adviser is the doctor of medical sciences, professor K.A. Alikhanova.
4. Biochemical and structural changes in the utero-placental complex of white, non-native rats when exposed to dust-salt aerosols of the Aral Sea.
The scientific adviser is Doctor of biological sciences, professor B.Z. Kultanov, I.L. Kopobaeva.
5.Development of the complete synthesis of Acyclovir and Abakovir under conditions of microwave activation.
The scientific adviser is Doctor of chemical sciences, assistant professor D.P. Khrustalev.
6.Study of the role of secondary infection in patients with multidrug-resistant tuberculosis.
The scientific adviser is A.V. Lavrinenko
7.Development of the composition and technology of obtaining new medicines for antimicrobial and expectorant action based on some representatives of the genus Thymus L.
The scientific adviser is Doctor of pharmaceutical sciences, associate professor S.A. Ivasenko
